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Mice that had received siRNA–invivofectamine complex were administrated hepatotoxic gapmers targeting ApoB (20 mg/kg), Hprt1 (80 mg/kg), or human Kif11 (80 mg/kg). Upper panels show plasma ALT; lower panels show plasma AST. ApoB (a,d), Hprt1 (b,e), and human Kif11 (c,f). (n = 3, mean ± S.D.) #Mouse was euthanized because of acute weight loss.
