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. 2016 Jul 27;6:30384. doi: 10.1038/srep30384

Figure 3. Inhibiting PI3Kδ results in similar suppression of IL-17 production as AKT inhibition from isolated Th17 cells.

Figure 3

CD4+/CD62L+ naïve T helper cells were isolated from an IL-17F reporter mouse which uses Thy1.1 expression as a marker for IL-17F production and then differentiated into Th17 cells. Th17 cells were then further isolated by sorting thy1.1+ cells on flow cytometer and then treated with inhibitor compounds on day 3 of differentiation. Compared to vehicle control, the PI3Kδ inhibitor results in strikingly similar inhibition of IL-17 production as an AKT inhibitor. *p < 0.05, compared to DMSO.