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FANCJ irons out G4 DNA Wrinkles. G-quadruplex (G4) DNA structures (inset) need to be resolved by G4-interacting proteins (e.g., FANCJ helicase) to provide a suitable template for replication and other DNA metabolic processes. Once FANCJ or other G4-interacting helicases remove the G4 DNA wrinkles, the protein machinery can smoothly copy, repair, or transcribe to maintain genomic stability and cellular homeostasis.
