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. 2016 Jul 1;7(7):31. doi: 10.3390/genes7070031

Figure 2.

Figure 2

Proposed models for how FANCJ protein interactions provide a mechanistic opportunity to resolve G4 structures to enable smooth DNA synthesis. (A) FANCJ interacts with the TLS polymerase REV1 at the site of a G4 structure, enabling it to catalyze DNA synthesis past the G4 obstacle. A REV-1 interacting polymerase is likely to also be involved; (B) FANCJ interacts with the BLM (or WRN) helicase to efficiently resolve the G4 DNA structure, making the single-strand template accessible to a replicative DNA polymerase. For either model, the role of FANCJ may prevail for leading or lagging strand DNA synthesis. See text for details.