Table 3. The effect of Zn(L)SCN on MDA levels and the activity of SOD, CAT and PGE2 in the gastric tissue from all experimental rats.
| Group | MDA (nmol/mg protein) | SOD (U/mg protein) | CAT (nmol/min/mg protein) | PGE2 (pg/mg protein) |
|---|---|---|---|---|
| Normal (CMC 0.5%) | 13.33 ± 0.92 | 50.50 ± 1.79 | 36.24 ± 1.13 | 342.35 ± 9.10 |
| HCl/EtOH | 77.94 ± 4.96** | 17.96 ± 1.21** | 15.86 ± 1.86** | 110.76 ± 3.59** |
| OMP 20 mg/kg | 16.70 ± 1.18* | 46.44 ± 2.38* | 37.20 ± 2.22* | 327.12 ± 3.72* |
| Zn(L)SCN 10 mg/kg | 61.88 ± 6.47*,# | 23.69 ± 1.99# | 23.31 ± 1.60*,# | 119.37 ± 4.81# |
| Zn(L)SCN 20 mg/kg | 31.90 ± 2.76* | 33.67 ± 2.59*,# | 26.28 ± 1.43*,# | 226.58 ± 4.59*,# |
| Zn(L)SCN 40 mg/kg | 21.59 ± 2.14* | 45.16 ± 1.91* | 38.72 ± 0.97* | 303.13 ± 6.06* |
| Zn(L)SCN 80 mg/kg | 16.11 ± 1.66* | 51.78 ± 2.23* | 41.02 ± 1.11* | 319.96 ± 5.34* |
Data are presented in the form of Mean ± SEM (n = 6).
*P < 0.05 vs ulcer control HCl/EtOH.
**P < 0.05 vs normal control.
#P < 0.05 vs OMP-treated group. (MDA) Malondialdehyde; (SOD) superoxide dismutase; (CAT) catalase; (PGE2) Prostaglandin E2; (CMC) carboxymethylcellulose; (HCl/EtOH) acidified ethanol; (OMP) omeprazole and (Zn(L)SCN) 2-morpholino-N-[1-(2-pyridyl)-ethylidene] ethanamine-k3N,N′,N″ bis (thiocyanato-kN) zin(II) [Zn(L)SCN].