Table 4. The effect of Zn(L)SCN on the level of IL-6, TNF-α and caspase-3 in the serum from all experimental rats.
| Group | IL-6 (pg/mL) | TNF-α (pg/mL) | Caspase-3 (ng/mL) |
|---|---|---|---|
| Normal (CMC 0.5%) | 1.74 ± 0.06 | 14.87 ± 1.25 | 2.71 ± 0.27 |
| HCl/EtOH | 13.42 ± 0.53** | 108.80 ± 4.88** | 18.88 ± 2.21** |
| OMP 20 mg/kg | 1.86 ± 0.08* | 18.95 ± 1.99* | 2.58 ± 0.23* |
| Zn(L)SCN 10 mg/kg | 5.39 ± 0.46*,# | 70.76 ± 3.43*,# | 14.19 ± 1.71# |
| Zn(L)SCN 20 mg/kg | 4.22 ± 0.17*,# | 52.85 ± 3.10*,# | 5.66 ± 0.43* |
| Zn(L)SCN 40 mg/kg | 2.74 ± 0.15* | 21.57 ± 1.27* | 2.01 ± 0.19* |
| Zn(L)SCN 80 mg/kg | 2.31 ± 0.07* | 17.34 ± 0.69* | 2.32 ± 0.20* |
Data are presented in the form of Mean ± SEM (n = 6).
*P < 0.05 vs ulcer control HCl/EtOH.
**P < 0.05 vs normal control.
#P < 0.05 vs OMP-treated group. (IL-6) Interlukin-6; (TNF-α) Tumor necrosis factor-α; (CMC) Carboxymethyl cellulose; (HCl/EtOH) acidified ethanol; (OMP) omeprazole and (Zn(L)SCN) 2-morpholino-N-[1-(2-pyridyl)-ethylidene] ethanamine-k3N,N′,N″ bis (thiocyanato-kN) zin(II) [Zn(L)SCN].