Table 7.
Analysis for smoking status difference (non-smoking and smoking) in LOX G473A genotype frequency distribution.
| Genotypes | Genotype Frequencies (%) | p | OR (95%CI) | |
|---|---|---|---|---|
| Cancer Groups | Control Groups | |||
| A. Lung Cancer | 200 (100.00) | 352 (100.00) | ||
| Non-smoking | 118 (59.00) | 256 (72.73) | ||
| GG | 75 (37.50) | 156 (44.30) | - | 1.00 (Ref.) |
| GA | 26 (13.00) | 90 (25.60) | 0.08 | 0.62 (0.37–1.05) |
| AA | 17 (8.50) | 10 (2.84) | <0.01 | 3.97 (1.70–9.29) * |
| Smoking | 82 (41.00) | 96 (27.27) | ||
| GG | 43 (21.50) | 57 (16.19) | - | 1.00 (Ref.) |
| GA | 22 (11.00) | 33 (9.38) | 0.67 | 0.86 (0.43–1.73) |
| AA | 17 (8.50) | 6 (1.70) | 0.03 | 3.25 (1.15–9.16) * |
| B. Colorectal Cancer | 335 (100.00) | 352 (100.00) | ||
| Non-smoking | 262 (78.21) | 256 (72.73) | ||
| GG | 136 (40.60) | 156 (44.30) | - | 1.00 (Ref.) |
| GA | 98 (29.25) | 90 (25.60) | 0.23 | 1.25 (0.87–1.81) |
| AA | 28 (8.36) | 10 (2.84) | <0.01 | 1.77 (1.21–2.59) * |
| Smoking | 73 (21.79) | 96 (27.27) | ||
| GG | 34 (10.15) | 57 (16.19) | - | 1.00 (Ref.) |
| GA | 32 (9.55) | 33 (9.38) | 0.14 | 1.67 (0.85–3.27) |
| AA | 7 (2.09) | 6 (1.70) | 0.41 | 1.30 (0.70–2.43) |
| C. Colon Cancer | 130 (100.00) | 352 (100.00) | ||
| Non-smoking | 100 (76.920 | 256 (72.73) | ||
| GG | 54 (41.54) | 156 (44.30) | - | 1.00 (Ref.) |
| GA | 38 (29.23) | 90 (25.60) | 0.38 | 1.25 (0.76–2.05) |
| AA | 8 (6.15) | 10 (2.84) | 0.10 | 1.51 (0.92–2.48) |
| Smoking | 30 (23.08) | 96 (27.27) | ||
| GG | 9 (6.92) | 57 (16.19) | - | 1.00 (Ref.) |
| GA | 16 (12.31) | 33 (9.38) | 0.07 | 2.33 (0.94–5.75) |
| AA | 5 (3.85) | 6 (1.70) | 0.04 | 2.11 (1.02–4.38) * |
| D. Rectum Cancer | 205 (100.00) | 352 (100.00) | ||
| Non-smoking | 162 (79.02) | 256 (72.73) | ||
| GG | 82 (40.00) | 156 (44.30) | - | 1.00 (Ref.) |
| GA | 60 (29.26) | 90 (25.60) | 0.26 | 1.28 (0.84–1.96) |
| AA | 20 (9.76) | 10 (2.84) | <0.01 | 1.86 (1.24–2.80) * |
| Smoking | 43 (20.98) | 96 (27.27) | ||
| GG | 25 (12.20) | 57 (16.19) | - | 1.00 (Ref.) |
| GA | 16 (7.81) | 33 (9.38) | 0.71 | 1.16 (0.53–2.55) |
| AA | 2 (0.98) | 6 (1.70) | 0.71 | 0.84 (0.34–2.09) |
Analysis for smoking status difference in LOX G473A genotypes performed by the unconditional logistic regression test; p values adjusted for age and sex; OR, odd ratio; CI, confidence interval. Ref., using GG as reference 1; * indicates significance statistically.