Table 8.
Analysis for smoking status difference (heavy and mild smoking) in LOX G473A genotype frequency distribution.
| Genotypes | Genotype Frequencies (%) | p | OR (95%CI) | |
|---|---|---|---|---|
| Cancer Groups | Control Groups | |||
| A. Lung Cancer | 200 (100.00) | 352 (100.00) | ||
| Smoking (Total) | 82 (41.00) | 96 (27.27) | ||
| Heavy-smoking | 66 (33.00) | 27 (7.67) | ||
| GG | 32 (16.00) | 17 (4.83) | - | 1.00 (Ref.) |
| GA | 18 (9.00) | 10 (2.84) | 0.47 | 0.67 (0.25–1.90) |
| AA | 16 (8.00) | 0 (0.00) | <0.01 | - * f |
| Mild-Smoking | 16 (8.00) | 69 (19.60) | ||
| GG | 11 (5.50) | 40 (11.36) | - | 1.00 (Ref.) |
| GA | 4 (2.00) | 23 (6.53) | 0.55 | 0.68 (0.19–2.41) |
| AA | 1 (0.50) | 6 (1.70) | 0.63 | 0.76 (0.25–2.34) |
| B. Colorectal Cancer | 335 (100.00) | 352 (100.00) | ||
| Smoking (Total) | 73 (21.79) | 96 (27.27) | ||
| Heavy-smoking | 48 (14.33) | 44 (12.50) | ||
| GG | 22 (6.57) | 27 (7.67) | - | 1.00 (Ref.) |
| GA | 22 (6.57) | 16 (4.55) | 0.21 | 1.77 (0.73–4.27) |
| AA | 4 (1.19) | 1 (0.28) | 0.16 | 2.36 (0.72–7.77) |
| Mild-Smoking | 25 (7.46) | 52 (14.77) | ||
| GG | 12 (3.58) | 30 (8.52) | - | 1.00 (Ref.) |
| GA | 10 (2.99) | 17 (4.83) | 0.40 | 1.57 (0.54–4.57) |
| AA | 3 (0.90) | 5 (1.42) | 0.98 | 1.01 (0.44–2.33) |
| C. Colon Cancer | 130 (100.00) | 352 (100.00) | ||
| Smoking (Total) | 30 (23.08) | 96 (27.27) | ||
| Heavy-smoking | 20 (15.38) | 44 (12.50) | ||
| GG | 6 (4.62) | 27 (7.67) | - | 1.00 (Ref.) |
| GA | 10 (7.69) | 16 (4.55) | 0.18 | 2.31 (0.68–7.84) |
| AA | 4 (3.08) | 1 (0.28) | 0.02 | 18.20 (1.47–225.19) * |
| Mild-Smoking | 10 (7.69) | 52 (14.77) | ||
| GG | 3 (2.31) | 30 (8.52) | - | 1.00 (Ref.) |
| GA | 6 (4.62) | 17 (4.83) | 0.71 | 0.64 (0.06–6.87) |
| AA | 1 (0.77) | 5 (1.42) | 0.73 | 1.54 (0.13–18.76) |
| D. Rectum Cancer | 205 (100.00) | 352 (100.00) | ||
| Smoking (Total) | 43 (20.98) | 96 (27.27) | ||
| Heavy-smoking | 28 (13.66) | 44 (12.50) | ||
| GG | 16 (7.80) | 27 (7.67) | - | 1.00 (Ref.) |
| GA | 12 (5.85) | 16 (4.55) | 0.56 | 1.35 (0.50–3.65) |
| AA | 0 (0.00) | 1 (0.28) | - | - |
| Mild-Smoking | 15 (7.32) | 52 (14.77) | ||
| GG | 9 (4.39) | 30 (8.52) | - | 1.00 (Ref.) |
| GA | 4 (1.95) | 17 (4.83) | 0.76 | 0.80 (0.21–3.15) |
| AA | 2 (0.98) | 5 (1.42) | 0.91 | 0.90 (0.13–6.00) |
Analysis for smoking status difference in LOX G473A genotypes performed by the unconditional logistic regression test; p values adjusted for age and sex; OR, odd ratio; CI, confidence interval; Mild smoker, a person used cigarette < average ASV, i.e., 30 pack-years in the lung cancer group and 20 pack-years in the colorectal cancer groups; heavy smoker, a person used cigarette ≥ average ASV. Ref., using GG as reference 1; * indicates significance statistically. * f Since 0 case for the genotype AA in the control group, the difference for cancer and control groups was analyzed by the Fisher exact test, the actual p value = 0.007.