Table 1.
Characteristics of eligible studies included in the meta-analysis.
| IL-17A rs2275913 and CAD | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | GG | GA | AA | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Shuang, L. [8] | 2015 | China | Asian | PCR-RFLP | 321:94/265:183 | 59.20 ± 10.85/ 60.10 ± 10.35 |
13 | 415/452 | 168/220 | 187/196 | 60/36 | 0.401 |
| Zheng, X.S. [11] | 2015 | China | Asian | PCR-RFLP | 280:92/280:92 | 62.15 ± 11.30/ 61.74 ± 10.95 |
13 | 372/372 | 162/179 | 170/163 | 40/30 | 0.398 |
| Geng, G.Y. [7] | 2015 | China | Asian | PCR-RFLP | 234:72/234:72 | 61.5 ± 10.5/ 60.3 ± 9.8 |
13 | 306/306 | 123/146 | 140/134 | 43/26 | 0.541 |
| Vargas-Alarcón, G. [9] | 2015 | Mexico | Caucasian | Taqman | 253:414/744:156 | 54 [49,58]/ 52 [47,58] |
14 | 898/667 | 616/439 | 259/202 | 23/26 | 0.648 |
| Zhang, X. [10] | 2011 | China | Asian | Sequencing PCR | 612:419/524:411 | 55.9 ± 10.1/ 55.2 ± 10.5 |
12 | 1031/935 | 290/266 | 535/489 | 206/180 | 0.093 |
| IL-17A rs3819025 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | AA | AG | GG | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Shuang, L. [8] | 2015 | China | Asian | PCR-RFLP | 321:94/265:183 | 59.20 ± 10.85/ 60.10 ± 10.35 |
13 | 415/448 | 179/212 | 177/180 | 59/56 | 0.07 |
| Zhang, X. [10] | 2011 | China | Asian | Sequencing PCR | 612:419/524:411 | 55.9 ± 10.1/ 55.2 ± 10.5 |
12 | 1031/935 | 635/554 | 358/342 | 38/39 | 0.125 |
| IL-17A rs3748067 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | TT | TC | CC | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Shuang, L. [8] | 2015 | China | Asian | PCR-RFLP | 321:94/265:183 | 59.20 ± 10.85/ 0.10 ± 10.35 |
10 | 415/448 | 301/339 | 91/95 | 23/14 | 0.03 |
| Zheng, X.S. [11] | 2015 | China | Asian | PCR-RFLP | 280:92/280:92 | 62.15 ± 11.30/ 61.74 ± 10.95 |
10 | 372/372 | 243/276 | 73/79 | 57/17 | <0.0001 |
| IL-17A rs3819024 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | AA | AG | GG | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Vargas-Alarcón, G. [9] | 2015 | Mexico | Caucasian | Taqman | 253:414/744:156 | 54 [49,58]/ 52 [47,58] |
14 | 898/667 | 615/434 | 259/209 | 24/24 | 0.851 |
| Zhang, X. [10] | 2011 | China | Asian | Sequencing PCR | 612:419/524:411 | 55.9 ± 10.1/ 55.2 ± 10.5 |
12 | 1031/935 | 230/219 | 542/470 | 259/246 | 0.850 |
| IL-17A rs8193037 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | GG | GA | AA | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Vargas-Alarcón, G. [9] | 2015 | Mexico | Caucasian | Taqman | 253:414/744:156 | 54 [49,58]/ 52 [47,58] |
14 | 898/667 | 763/578 | 126/83 | 9/6 | 0.125 |
| Zhang, X. [10] | 2011 | China | Asian | Sequencing PCR | 612:419/524:411 | 55.9 ± 10.1/ 55.2 ± 10.5 |
12 | 1031/935 | 896/759 | 126/166 | 9/10 | 0.784 |
| Zhang XL [17] | 2010 | China | Asian | PCR-RFLP | 291:229/283:197 | 55.9 ± 10.1/ 55.2 ± 10.5 |
11 | 520/480 | 452/390 | 63/85 | 5/5 | 0.878 |
| IL-17A rs819336 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Sample Size (Case/Control) | TT | TC | CC | HWE of Control | |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Vargas-Alarcón, G. [9] | 2015 | Mexico | Caucasian | Taqman | 253:414/744:156 | 54 [49,58]/ 52 [47,58] |
898/667 | 546/409 | 303/221 | 46/34 | 0.561 | |
| IL-17A rs4711998 and CAD | ||||||||||||
| Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | AA | AG | GG | HWE of Control |
| (Case/Control) | (Case/Control) | (Case/Control) | ||||||||||
| Zhang, X. [10] | 2011 | China | Asian | Sequencing PCR | 612:419/524:411 | 55.9 ± 10.1/ 55.2 ± 10.5 |
12 | 1031/935 | 626/593 | 349/295 | 56/47 | 0.194 |
PCR-RFLP: Polymerase chain reaction- restriction fragment length polymorphism.