Table 2.
Pooled ORs and 95% CIs of the association between IL-17A rs2275913, rs3819024, rs3819025, rs8193037, rs3748067, rs4711998, rs8193036, and CAD risks.
| IL-17A rs2275913 and CAD | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic Model | N | OR (95% CI) | p | padj | I2 (%) | Genetic Model | N | OR (95% CI) | p | padj | I2 (%) | ||||
| GG vs. AA | Overall | 5 | 0.75 (0.50, 1.12) | 0.16 | - | 75 | GG vs. GA | Overall | 5 | 0.94 (0.84, 1.06) | 0.32 | - | 9 | ||
| Small size | 3 | 0.53 (0.40, 0.71) | <0.0001 | <0.0001 | 0 | Small size | 3 | 0.82 (0.69, 0.98) | 0.03 | 0.21 | 0 | ||||
| Large size | 2 | 1.15 (0.71, 1.86) | 0.57 | - | 60 | Large size | 2 | 1.04 (0.90, 1.21) | 0.60 | - | 0 | ||||
| Asian | 4 | 0.68 (0.40, 1.14) | 0.03 | 0.21 | 69 | Asian | 4 | 0.89 (0.78, 1.02) | 0.10 | - | 0 | ||||
| Caucasian | 1 | 1.59 (0.89, 2.82) | 0.12 | - | N.A | Caucasian | 1 | 1.09 (0.88, 1.37) | 0.42 | - | N.A | ||||
| GG vs. GA/AA | Overall | 5 | 0.89 (0.74, 1.06) | 0.18 | - | 59 | G vs. A | Overall | 5 | 0.88 (0.75, 1.04) | 0.15 | - | 75 | ||
| Small size | 3 | 0.76 (0.64, 0.90) | 0.001 | 0.007 | 0 | Small size | 3 | 0.77 (0.68, 0.87) | <0.0001 | <0.0001 | 0 | ||||
| Large size | 2 | 1.05 (0.91, 1.21) | 0.50 | - | 0 | Large size | 2 | 1.05 (0.90, 1.22) | 0.57 | - | 50 | ||||
| Asian | 4 | 0.83 (0.71, 0.98) | 0.02 | 0.14 | 33 | Asian | 4 | 0.83 (0.71, 0.97) | 0.02 | 0.14 | 65 | ||||
| Caucasian | 1 | 1.13 (0.92, 1.40) | 0.25 | - | N.A | Caucasian | 1 | 1.15 (0.96, 1.38) | 0.14 | - | N.A | ||||
| IL-17A rs8193037 and CAD | |||||||||||||||
| Genetic Model | N | OR (95% CI) | p | padj | I2 (%) | Genetic Model | N | OR (95% CI) | p | padj | I2 (%) | ||||
| GG vs. AA | Overall | 3 | 1.12 (0.61, 2.02) | 0.72 | - | 0 | GG vs. GA | Overall | 3 | 1.28 (0.87, 1.89) | 0.21 | - | 80 | ||
| Asian | 2 | 1.26 (0.60, 2.61) | 0.54 | - | 0 | Asian | 2 | 1.56 (1.27, 1.91) | <0.0001 | <0.0001 | 0 | ||||
| Caucasian | 1 | 0.88 (0.31, 2.49) | 0.81 | - | N.A | Caucasian | 1 | 0.87 (0.65, 1.17) | 0.36 | - | N.A | ||||
| GG vs. GA/AA | Overall | 3 | 1.27 (0.87, 1.85) | 0.21 | - | 80 | G vs. A | Overall | 3 | 1.23 (0.88, 1.73) | 0.22 | - | 79 | ||
| Asian | 2 | 1.54 (1.26, 1.88) | <0.0001 | <0.0001 | 0 | Asian | 2 | 1.47 (1.22, 1.76) | <0.0001 | <0.0001 | 0 | ||||
| Caucasian | 1 | 0.87 (0.65, 1.16) | 0.35 | - | N.A | Caucasian | 1 | 0.88 (0.67, 1.15) | 0.35 | - | N.A | ||||
| IL-17A rs3819024 and CAD | IL-17A rs3819025 and CAD | ||||||||||||||
| Genetic Model | N | OR (95% CI) | p | padj | I2 (%) | N | OR (95% CI) | p | padj | I2 (%) | |||||
| AA vs. GG | 2 | 1.06 (0.84, 1.33) | 0.65 | - | 16 | AA vs. GG | 2 | 0.95 (0.70, 1.30) | 0.76 | - | 32 | ||||
| AA vs. GA | 2 | 1.02 (0.82, 1.28) | 0.85 | - | 51 | AA vs. GA | 2 | 1.02 (0.87, 1.19) | 0.82 | - | 48 | ||||
| AA vs. GA/GG | 2 | 1.05 (0.85, 1.29) | 0.68 | - | 51 | AA vs. GA/GG | 2 | 0.98 (0.76, 1.27) | 0.90 | - | 62 | ||||
| A vs. G | 2 | 1.05 (0.95, 1.16) | 0.37 | - | 39 | A vs. G | 2 | 0.99 (0.80, 1.22) | 0.89 | - | 65 | ||||
| IL-17A rs8193036 and CAD | IL-17A rs3748067 and CAD | ||||||||||||||
| Genetic Model | N | OR (95% CI) | P | padj | I2 (%) | Genetic Model | N | OR (95% CI) | P | padj | I2 (%) | ||||
| TT vs. CC | 1 | 0.99 (0.62, 1.57) | 0.95 | - | N.A | TT vs. CC | 2 | 0.37 (0.18, 0.74) | 0.005 | 0.04 | 61 | ||||
| TT vs. TC | 1 | 0.97 (0.78, 1.21) | 0.81 | - | N.A | TT vs. TC | 2 | 0.94 (0.74, 1.20) | 0.61 | - | 0 | ||||
| TT vs. TC/CC | 1 | 0.98 (0.79, 1.20) | 0.81 | - | N.A | TT vs. TC/CC | 2 | 0.75 (0.60, 0.93) | 0.009 | 0.06 | 30 | ||||
| T vs. C | 1 | 0.98 (0.83, 1.17) | 0.84 | - | N.A | T vs. C | 2 | 0.66 (0.44, 0.98) | 0.04 | 0.28 | 79 | ||||
| IL-17A rs4711998 and CAD | |||||||||||||||
| Genetic Model | N | OR (95% CI) | P | padj | I2 (%) | ||||||||||
| AA vs. GG | 1 | 0.89 (0.59, 1.33) | 0.56 | - | N.A | ||||||||||
| AA vs. GA | 1 | 0.89 (0.74, 1.08) | 0.24 | - | N.A | ||||||||||
| AA vs. GA/GG | 1 | 0.89 (0.74, 1.07) | 0.22 | - | N.A | ||||||||||
| A vs. G | 1 | 0.91 (0.78, 1.06) | 0.24 | - | N.A | ||||||||||
N.A: not applicable.