Table 2.
Haplotype | Overall breast cancer | Breast cancer (age at diagnosis <45 years) | Breast cancer (age at diagnosis ≥45 years) | P heterogeneity b | ||||||
---|---|---|---|---|---|---|---|---|---|---|
rs805510 - rs7297051- rs1871152 | Frequency | OR (95 % CI)a | P value | Frequency | OR (95 % CI)a | P value | Frequency | OR (95 % CI)a | P value | |
C-C-A | 0.51 | 1.00 (Ref) | Ref | 0.52 | 1.00 (Ref) | Ref | 0.51 | 1.00 (Ref) | Ref | - |
C-C-G | 0.24 | 0.92 (0.89–0.95) | 7 × 10-8 | 0.22 | 0.94 (0.89–1.00) | 0.04 | 0.24 | 0.92 (0.89–0.95) | 4 × 10-7 | 0.24 |
C-T-A | 0.09 | 0.90 (0.87–0.95) | 3 × 10-6 | 0.09 | 0.96 (0.89–1.03) | 0.28 | 0.09 | 0.90 (0.86–0.94) | 4 × 10-7 | 0.09 |
C-T-G | 0.03 | 0.89 (0.82–0.96) | 2 × 10-3 | 0.03 | 0.85 (0.73–0.98) | 0.02 | 0.03 | 0.89 (0.82–0.96) | 3 × 10-3 | 0.37 |
T-T-A | 0.04 | 0.82 (0.77–0.88) | 9 × 10-9 | 0.04 | 0.76 (0.67–0.87) | 5 × 10-5 | 0.04 | 0.83 (0.76–0.85) | 5 × 10-8 | 0.19 |
T-T-G | 0.07 | 0.79 (0.76–0.83) | 3 × 10-23 | 0.06 | 0.78 (0.71–0.85) | 5 × 10-8 | 0.07 | 0.81 (0.77–0.85) | 3 × 10-18 | 0.45 |
Rare | 0.01 | 0.88 (0.79–0.99) | 0.04 | 0.01 | 0.90 (0.72–1.13) | 0.37 | 0.01 | 0.88 (0.78–0.99) | 0.04 | 0.45 |
aAdjusted for studies and the top principal components. b P for heterogeneity between cases with age at diagnosis <45 years and ≥45 years. Ref reference