Table 2.

Associations between common haplotypes derived using lead single nucleotide polymorphisms and breast cancer risk in women of European ancestry

Haplotype	Overall breast cancer			Breast cancer (age at diagnosis <45 years)			Breast cancer (age at diagnosis ≥45 years)			P heterogeneity b
rs805510 - rs7297051- rs1871152	Frequency	OR (95 % CI)a	P value	Frequency	OR (95 % CI)a	P value	Frequency	OR (95 % CI)a	P value
C-C-A	0.51	1.00 (Ref)	Ref	0.52	1.00 (Ref)	Ref	0.51	1.00 (Ref)	Ref	-
C-C-G	0.24	0.92 (0.89–0.95)	7 × 10-8	0.22	0.94 (0.89–1.00)	0.04	0.24	0.92 (0.89–0.95)	4 × 10-7	0.24
C-T-A	0.09	0.90 (0.87–0.95)	3 × 10-6	0.09	0.96 (0.89–1.03)	0.28	0.09	0.90 (0.86–0.94)	4 × 10-7	0.09
C-T-G	0.03	0.89 (0.82–0.96)	2 × 10-3	0.03	0.85 (0.73–0.98)	0.02	0.03	0.89 (0.82–0.96)	3 × 10-3	0.37
T-T-A	0.04	0.82 (0.77–0.88)	9 × 10-9	0.04	0.76 (0.67–0.87)	5 × 10-5	0.04	0.83 (0.76–0.85)	5 × 10-8	0.19
T-T-G	0.07	0.79 (0.76–0.83)	3 × 10-23	0.06	0.78 (0.71–0.85)	5 × 10-8	0.07	0.81 (0.77–0.85)	3 × 10-18	0.45
Rare	0.01	0.88 (0.79–0.99)	0.04	0.01	0.90 (0.72–1.13)	0.37	0.01	0.88 (0.78–0.99)	0.04	0.45

^aAdjusted for studies and the top principal components. ^b P for heterogeneity between cases with age at diagnosis <45 years and ≥45 years. Ref reference