TABLE III.

Predictors of Disease Specific Survival (DSS) for Patients With Adrena Cortical Carcinoma Who Underwent Surgical Resection

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P-value	HR (95%CI)	P-value
Gender		0.893
Female	Ref.
Male	0.96 (0.50–1.81)
Age		0.347
<50 years	Ref.
≥50 years	0.99 (0.97–1.01)
ASA physical status		0.092
1–2	Ref.
3–4	2.13 (0.88–5.17)
Coronary artery disease		0.205
No	Ref.
Yes	1.86 (0.71–4.87)
Chronic heart failure		0.309
No	Ref.
Yes	0.35 (0.05–2.61)
Chronic obstructive pulmonary disease		0.164
No	Ref.
Yes	1.95 (0.76–5.05)
Chronic renal insufficiency		0.074
No	Ref.
Yes	3.86 (0.88–17.0)
Diabetes mellitus		0.002
No	Ref.
Yes	3.36 (1.55–7.28)
Incidentaloma		0.788
No	Ref.
Yes	0.92 (0.48–1.74)
Functional status		0.229
No	Ref.
Yes	1.50 (0.77–2.93)
Tumor size		0.987
≤5 cm	Ref.
>5 cm	0.99 (0.78–1.26)
Preoperative chemo-radiotherapy		0.149
No	Ref.
Yes	2.91 (0.68–12.5)
Other organ resected		0.074
No	Ref.
Yes	1.79 (0.94–3.41)
IVC exclusion		0.064
No	Ref.
Yes	2.51 (0.95–6.63)
AJCC tumor status		<0.001
T stages I–II	Ref.		Ref.
T stages III–IV	4.54 (2.07–9.99)		3.91 (1.76–8.73)	0.001
AJCC node status		0.008
N0	Ref.
N1	1.63 (1.13–2.35)
AJCC metastasis status		0.004		0.028
M0	Ref.		Ref.
M1	2.84 (1.39–5.79)		2.42 (1.10–5.35)
Margin status		<0.001
R0	Ref.
R1/R2	3.83 (1.88–7.77)
Complications		0.004
No	Ref.
Yes	2.90 (1.40–6.01)
Readmission within 90 days		0.039
No	Ref.
Yes	2.06 (1.03–4.09)
NLR		0.002		0.025
≤5	Ref.		Ref.
>5	2.85 (1.49–5.47)		2.21 (1.10–4.43)
PLR		0.757
≤190	Ref.
>190	0.90 (0.47–1.73)
Post-operative chemotherapy		0.438
Not performed	Ref.
Performed	1.42 (0.58–3.52)
Post-operative radiotherapy		0.893
Not performed	Ref.
Performed	1.07 (0.37–3.07)
Post-operative chemotherapy with mitotane		0.372
Not performed	Ref.
Performed	1.38 (0.67–2.81)

IVC, inferior vena cava; P-values ≤ 0.05 are reported in bold and indicate statistically significant results.