A, The template of cortical AD-affected regions. B and C, Percentage of individuals with normal and abnormal cortical thickness, fludeoxyglucose positron emission tomography (FDG-PET), and hippocampal volume (HV) and 0, 1, and more than 1 abnormal neurodegenerative biomarker for Berkley Aging Cohort (BAC) NC cases, Alzheimer's Disease Neuroimaging Initiative (ADNI) NC cases, and ADNI AD cases.