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Peripheral neuropathies and endoplasmic reticulum (ER) stress-mediated therapies.
(A) Different neuropathies are associated with ER stress contributing to axonal degeneration. (B) Targeting ER stress may promote axonal regeneration. Strategies to alleviate ER stress may include the use of chemical chaperones and unfolded protein response enhancers (gene therapy or small molecules).
