TABLE 2.
Metabolite Levels and Hemodynamic Indexes of RV-PV Function
| Metabolite | RAP (Rest) | mPAP (Rest) | PAWP (Rest) | PVR (Rest) | PVR (Exercise) | ΔPQ (Exercise) |
|---|---|---|---|---|---|---|
| Arg/NO metabolism | ||||||
| Arginine | −0.29 (0.014) | −0.44 (<0.001) | −0.31 (0.007) | −0.31 (0.008) | −0.23 (0.058) | −0.30 (0.013) |
| Citrulline | −0.12 (0.337) | 0.08 (0.515) | 0.01 (0.940) | 0.21 (0.081) | 0.22 (0.069) | 0.32 (0.007) |
| Ornithine | 0.014 (0.907) | 0.05 (0.682) | 0.03 (0.780) | 0.02 (0.880) | 0.05 (0.703) | 0.29 (0.013) |
| ADMA | 0.13 (0.297) | 0.12 (0.301) | −0.04 (0.757) | 0.16 (0.195) | 0.14 (0.233) | 0.30 (0.011) |
| SDMA | 0.14 (0.234) | 0.27 (0.025) | 0.11 (0.373) | 0.28 (0.017) | 0.36 (0.002) | 0.37 (.001) |
| Arg/(Orn+Citr) | −0.21 (0.074) | −0.44 (<0.001) | −0.29 (0.014) | −0.36 (0.002) | −0.31 (0.009) | −0.53 (<0.001) |
| Arg/NO score* | 0.32 (0.007) | 0.44 (0.001) | 0.31 (0.019) | 0.39 (0.001) | 0.32 (0.006) | 0.53 (<0.001) |
| IDO metabolites | ||||||
| Kynurenine | 0.50 (<0.001) | 0.46 (<0.001) | 0.35 (0.002) | 0.30 (0.012) | 0.38 (0.001) | 0.48 (<0.001) |
| Anthranilate | 0.16 (0.187) | 0.39 (0.001) | 0.12 (0.302) | 0.43 (<0.001) | 0.43 (<0.001) | 0.49 (<0.001) |
| Kynurenate | 0.17 (0.168) | 0.26 (0.032) | 0.13 (0.262) | 0.29 (0.014) | 0.28 (0.02) | 0.34 (0.004) |
| Quinolinate | 0.44 (<0.001) | 0.43 (<0.001) | 0.26 (0.028) | 0.32 (0.007) | 0.39 (0.001) | 0.53 (<0.001) |
| IDO-TM score* | 0.40 (<0.001) | 0.46 (<0.001) | 0.29 (0.011) | 0.41 (<0.001) | 0.45 (<0.001) | 0.55 (<0.001) |
| Purine metabolites | ||||||
| Inosine | 0.31 (0.008) | 0.28 (0.020) | 0.26 (0.027) | 0.14 (0.250) | 0.16 (0.188) | 0.34 (0.004) |
| Xanthosine | 0.28 (0.021) | 0.39 (0.001) | 0.23 (0.052) | 0.27 (0.329) | 0.29 (0.051) | 0.47 (<0.001) |
| Xanthine | 0.36 (0.002) | 0.34 (0.004) | 0.24 (0.040) | 0.24 (0.044) | 0.25 (0.033) | 0.40 (0.001) |
| Uric acid | 0.38 (0.001) | 0.45 (<0.001) | 0.35 (0.003) | 0.39 (0.001) | 0.33 (0.005) | 0.23 (0.054) |
| Allantoin | 0.11 (0.363) | 0.25 (0.038) | 0.17 (0.165) | 0.31 (0.009) | 0.26 (0.029) | 0.24 (0.043) |
| Purine score* | 0.47 (<0.001) | 0.46 (<0.001) | 0.53 (<0.001) | 0.39 (0.001) | 0.36 (0.002) | 0.45 (<0.001) |
| TCA cycle | ||||||
| Malate | 0.27 (0.022) | 0.35 (0.002) | 0.20 (0.092) | 0.39 (0.001) | 0.30 (0.011) | 0.33 (0.005) |
| Succinate | 0.13 (0.269) | 0.39 (0.001) | 0.15 (0.202) | 0.52 (<0.001) | 0.33 (0.005) | 0.24 (0.041) |
| Aconitate | 0.15 (0.217) | 0.177 (0.162) | 0.16 (0.177) | 0.34 (0.004) | 0.30 (0.013) | 0.31 (0.010) |
| Isocitrate | 0.12 (0.335) | 0.23 (0.051) | 0.16 (0.196) | 0.28 (0.017) | 0.21 (0.081) | 0.16 (0.175) |
| TCA score* | 0.32 (0.007) | 0.4 (0.001) | 0.22 (0.09) | 0.42 (<0.0001) | 0.32 (0.006) | 0.28 (0.02) |
| Known biomarker | ||||||
| NT-proBNP | 0.14 (0.261) | 0.40 (0.001) | 0.40 (0.001) | 0.30 (0.013) | 0.33 (0.007) | 0.38 (0.001) |
Values are β-coefficients (p value) and are presented to describe associations between log-transformed metabolite levels and hemodynamic measurements.
*
Multimarker scores described in Methods.
ADMA = asymmetric dimethylarginine; Arg/NO = arginine/nitric oxide; IDO-TM = indoleamine 2,3-dioxygenase tryptophan metabolite; Orn+Citr = ornithine plus citrulline; RV-PV = right ventricular-pulmonary vascular; SDMA = symmetric dimethylarginine; TCA = tricarboxylic acid; other abbreviations as in Table 1.