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. Author manuscript; available in PMC: 2017 Jan 19.
Published in final edited form as: J Am Coll Cardiol. 2016 Jan 19;67(2):174–189. doi: 10.1016/j.jacc.2015.10.072

TABLE 4.

Validation Cohort: Metabolite Levels and RV-PV Function

Pathway RAP (Rest) mPAP (Rest) PAWP (Rest) PVR (Rest) PVR (Exercise) ΔPQ (Exercise)
Arg/NO metabolites 0.34 (0.004) 0.36 (0.003) 0.26 (0.026) 0.35 (0.014) 0.28 (0.016) 0.22 (0.064)
IDO metabolites 0.28 (0.018) 0.43 (<0.001) 0.23 (0.042) 0.30 (0.010) 0.28 (0.019) 0.36 (0.002)
Purine metabolites 0.14 (0.25) 0.31 (0.013) 0.07 (0.58) 0.21 (0.07) 0.26 (0.027) 0.20 (0.10)
TCA metabolites 0.26 (0.027) 0.36 (0.003) 0.17 (0.19) 0.27 (0.024) 0.32 (0.007) 0.28 (0.019)

Values are β-coefficients (p values) for regression analyses in the validation cohort relating each metabolic pathway score to hemodynamic measurements. Bold indicates metabolites with β-coefficients that achieved statistical significance with p < 0.0125.

Abbreviations as in Tables 1 and 2.