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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Nanomedicine. 2013 Oct 2;10(3):619–627. doi: 10.1016/j.nano.2013.09.004

Figure 4. IVIS imaging of DH guinea pigs intravenously injected with MAbCII liposome.

Figure 4

Animals were IVIS imaged at 24 hours after injection. (A and B) IVIS scan images of young and older guinea pig (n=12 for each age group). (C) IVIS imaging of cartilages from dissected knee joints; (H) total integrated intensity of fluorescence (ROI) in femoral and tibial condyles was quantitated and normalized using imaging software. (D, E, F and G) Histopathology of Hematoxylin and Eosin (H&E) stained sections of articular knee cartilage from young & old GP showing regional variation in morphology. Tibial condyles were decalcified, embedded and 60 H&E-stained sections from each specimen were prepared with a constant interval of 100 μm to survey the articular cartilage. (I) These sections were then graded by an observer using a modified Mankin scale (normal; grade 0–2, slight; grade 3–5, moderate; grade 6–8 and severe; grade 9–11).