TABLE 3.

Change in FIC after a Cryptosporidium challenge^a

Outcome category	Illness periodb	P value	Resolution periodb	P value
Indole concn (mM)
No oocysts or diarrhea	3.43 ± 1.20	0.0001	2.92 ± 1.30	0.0001
Oocysts + diarrhea	1.41± 0.91		1.60 ± 0.68
Change in indole concn (mM)
No oocysts or diarrhea	0.023 ± 1.21	0.053	−0.31 ± 1.44	0.61
Oocysts + diarrhea	−0.34 ± 0.75		−0.13 ± 0.92
Change in indole concn (%)
No oocysts or diarrhea	7.9 ± 9.3	0.028	−2.10 ± 43.1	0.41
Oocysts + diarrhea	−16.3 ± 9.5		33.1 ± 39.5

^aSubjects in each outcome category (no oocysts or diarrhea, n = 32; oocysts plus diarrhea, n = 18) were tested during the illness period and/or after resolution of the infection and diarrhea. The median indole concentration, change in indole concentration, and percent change are shown along with 95% confidence intervals for each parameter. For each volunteer, the change and percent change in indole concentration were calculated on the basis of the baseline indole concentration. P values were calculated by using Student's t test with or without Welch's correction.

^bValues are means ± standard deviations.