Fig. 2.

Mutation burden in human tumors.

The median values for mutation frequencies in human tumors. Data are taken from refs. [91] and [92]. MSS microsatellite stable, MSI microsatellite unstable. Frequencies for melanoma also include those from refs. [93], [94] and [95] (desmoplastic). Basal cell skin carcinoma numbers are from ref. [96]. Squamous cell carcinoma frequencies include those of refs. [97] and [98]. Normal skin values from ref. [71]. PDE is colorectal carcinomas with DNA polymerase ∂/ε proofreading mutations. Mutation frequency data are from ref. [99]. Where more than one study has been reported, approximate mean values are presented. Skin and skin tumors are shown in red.