Fig. 1.

Comparisons between focal segmental glomerulosclerosis (FSGS) and minimal-change disease (MCD) patient samples. Comparisons of all metabolites from urine of patients with FSGS (n=8) or MCD (n=10). The y axis is the negative log₁₀ of p values (a higher value indicates greater significance), and the xaxis is the difference in signal intensity between two experimental groups as measured in log₂ space. The volcano plot displays the relationship between fold change and significance between the two studied groups. Metabolites significantly differentiated are color coded, and important ones are labeled (p value<0.05, fold change>2).