Table 1.

Effects of chronic (14-day) escalating-dose (45 up to 90 mg/kg/day) “binge” cocaine, acute (1-day) withdrawal (WD) and chronic (14-day) WD with opioid receptor antagonist naloxone (NXN, 1 mg/kg) on body weight (g) and plasma corticosterone (ng/ml) levels.

	14-day-dose	Escalating Cocaine	1-day	WD	1-day +	WDNaloxone	14-day	WD
	Saline	Cocaine	Saline	Cocaine	Saline	Cocaine	Saline	Cocaine
Body weight	244±2	177±3**	249±2	173±3**	265±3	170±4**	276±3	239±5*
Corticosterone	15±5	159±52**	129±37	102±41	127±26	100±38	122±32	98±32

^*p<0.05,

^**p<0.01 vs. Saline control. n=6–7.