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. 2016 Jul 6;88(14):7213–7221. doi: 10.1021/acs.analchem.6b01394

Figure 2.

Figure 2

Challenges for electrochemical analysis of thiols. (a) Cyclic voltammograms for glutathione (GSH; 10 μM) with gold electrode show no obvious oxidation or reduction peaks, consistent with observations that thiols do not readily exchange electrons. (b) Thiols can self-assemble on gold and potentially attenuate electrochemical signals. (c) Input–output curves show progressive attenuation of Fc oxidation, presumably because GSH self-assembly blocks the gold electrode. (d) GSH attenuation of Fc oxidation is not reversed by replacing the electrode in fresh Fc–Ru3+ mediator solution.