a) Static autoregulation curve of cortical Doppler flux show preserved autoregulation with an increase of ICP at CPP 70 and 50 mmHg and impaired autoregulation at 30 mmHg. b) Negative values of induced cerebrovascular reactivity (iCVRx) at physiological CPP of 70 mmHg indicated normal cerebrovascular reactivity. After ICP elevation, a rise in iCVRx indicated impairment of cerebrovascular reactivity at CPP of 50 mmHg. c) At normal CPP of 70 mmHg, induced intracranial pressure reactivity (iPRx) has zero or negative values, indicating preserved intracranial pressure reactivity. In contrast, when CPP was decreased by ICP increase, an increase in PRx indicated impaired intracranial pressure reactivity at CPP of 50 mmHg. All data are presented as Mean±SEM, n=10,*=p<0.05, **=p<0.01.