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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: J Drug Abuse. 2016 Apr 22;2(2):22. doi: 10.21767/2471-853x.100022

Figure 2. Impact of dmPFC Ifenprodil on cue-elicited responding in saline-, sucrose- and cocaine-trained rats.

Figure 2

Rats with a 10-day history of extended access (6 h/d) to either saline, sucrose, or cocaine received an intra-dmPFC infusion of the GluN2B antagonist, ifenprodil, or vehicle prior to opportunity to engage in cue-elicited responding at 3 days of withdrawal. (A). Cocaine-trained rats exhibited greater lever pressing than sucrose-trained rats following a vehicle, but an ifenprodil, infusion. Both cocaine- and sucrose-trained rats exhibited greater lever pressing than saline-trained rats under both conditions. *p<0.05 vs. Saline; +p<0.05 vs. Sucrose (LSD post-hoc tests).