Table 1.

Summary of the effects of a history of extended-access to IV cocaine upon the protein expression of GluN2A within both the vmPFC and dmPFC, as well as GluN2b within the vmPFC. As a priori comparisons of protein expression failed to indicate differences between Sal1h and Sal6h animals (t-tests, p’s>0.05), the data for the two saline self-administering groups were collapsed (Saline) prior to statistical comparison with that from cocaine self-administering animals. The numbers represent the mean optical density ± SEMs of the number of animals indicated in parentheses.

Protein	Region	3 Days Withdrawal			30 days Withdrawal
		Saline (n=22–23)	Cocaine (n=6–7)	Statistical Result	Saline (n=22–23)	Cocaine (n=11)	Statistical Result
GluN2A	vmPFC	100 ± 5.38	108.8 ± 3.09	t(26)=0.83, p=0.41	100 ± 3.78	91.60 ± 9.04	t(32)=1.01, p=0.32
	dmPFC	100 ± 3.17	113.38 ± 10.33	t(28)=1.66, p=0.11	100 ± 4.55	113.92 ± 7.50	t(31)=1.67, p=0.11
GluN2B	vmPFC	100 ± 6.01	107.67 ± 14.76	t(26)=0.56, p=0.58	100 ± 2.85	91.93 ± 9.24	t(32)=1.07, p=0.29