Table 1.

Genes with polymorphisms that influence the vaccine induced antibody level (selected studies).

Vaccine	Gene(s)	Function	Study	n	Remarks	Reference
HBV	CD11a (ITGAL)	part of LFA-1	43 candidate SNPs across 133 genes1	662	reproduced in second group (n=393)	Hennig et al. 2008
	HLA-DR, HLA-DP	HLA class II molecules	GWAS2	1683	reproduced in second group (n=1931)	Png et al. 2011
	HLA Class III		GWAS2	1683	reproduced in second group (n=1931)	Png et al. 2011
Measles	CD46	co-receptor	66 candidate SNPs across 3 genes3	744	replication study, prev. identified	Ovsyannikova et al. 2011
Influenza	HLA-DRB1, HLA-DQB1	HLA class II molecules	HLA class II alleles4	73		Gelder et al. 2002
	HLA-A	HLA class I molecule	HLA class I and class II alleles5	184		Poland et al. 2008
	IL6, IL12B, IFNB1	cytokine	candidate SNPs in cytokines5	184	SNPs in coding or regulatory region only	Poland et al. 2008
	IL1R1,IL2RA, IL10RA,IL12RB2, IL1RN	cytokine receptor	candidate SNPs in cytokine receptors5	184	SNPs in coding or regulatory region only	Poland et al. 2008
	NAPSA, GLMP, GM2A, DYNL1, SNX29, TAP2,FGD2	antigen transport and processing	GWAS and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	JUP, FBLN5	cell junction and adhesion	genotype and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	OAS1	antiviral response	genotype and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	LST1	lymphocyte proliferation inhibition	genotype and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	CHST13, PAM	metabolism	genotype and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	RPL14, NAPSB, DIP2A, LRRC37A4, NSG1, HRC2	various or unknown	genotype and gene expression6	199	reproduced in second group (n=125)	Franco et al. 2013
	IFNL3	cytokine	2 candidate SNPs in IFNL3 gene7	196	reproduced in healthy volunteers (n=28)	Egli et al. 2014

¹infants

²Indonesian population over 5 y of age

³schoolchildren

⁴influenza risk group according to ACIP

⁵18–40 y old male Caucasians

⁶18–40 y old males, ethnically homogeneous

⁷immunosuppressed patients