Table 1. Ang71 challenge following adoptive transfer of cells/sera from 17D-204-vaccinated mice into naive mice.
Survival Outcome | Average Survival Time (AST) | |||||
---|---|---|---|---|---|---|
Adoptive Transfer | # Alive | # Dead | Percent Survival | P-value a | Days ± SD | P-value b |
Mock-Vaccinated Total Splenocytes +Serum | 0 | 6 | 0.0 | n/a | 7.58±0.49 | n/a |
17D-204 Immunized CD4 | 5 | 3 | 62.5 | ** | 6.33±0.58 | * |
17D-204 Immunized CD8 | 0 | 8 | 0.0 | ns | 7.50±0.53 | ns |
17D-204 Immunized CD19 | 3 | 5 | 37.5 | * | 7.00±0.71 | ns |
17D-204 Immunized Serum | 6 | 2 | 75.0 | ** | 7.50±0.71 | ns |
17D-204 Immunized CD4, CD8 | 4 | 4 | 50.0 | * | 6.75±0.29 | ns |
17D-204 Immunized CD4, CD8, Serum | 8 | 0 | 100.0 | *** | n/a | n/a |
17D-204 Immunized CD4, CD8, CD19, Serum | 7 | 0 | 100.0 | *** | n/a | n/a |
17D-204 Immunized Total Splenocytes + Serum | 5 | 0 | 100.0 | *** | n/a | n/a |
a p values were calculated using a one-tailed chi-squared test compared to mock. ns, not significant; *, p ≤ 0.05; **, p ≤ 0.005; ***, p ≤ 0.0005.
b p values were calculated using a one-way ANOVA with Tukey's multiple comparisons test compared to mock. ns, not significant; *, p ≤ 0.05.