Total 125I-Aβ40 brain clearance (BCITotal(%)) (A), BBB 125I-Aβ40 clearance (BCIBBB(%)) (B) and clearance of 125I-Aβ40 by brain degradation (BCIDegradation(%)) (C) from the brain of C57BL/6, BALB/c, FVB/N and SJL/J wild-type mice. (D) Representative western blot and densitometry analysis of P-gp, LRP1 and protein loading control (GAPDH) in the brain tissue of C57BL/6, BALB/c, FVB/N and SJL/J wild-type mice. (E) Representative western blot quantitative fold change for IDE, NEP and protein loading control (GAPDH) in the brain tissue of C57BL/6, BALB/c, FVB/N and SJL/J wild-type mice. The data are expressed as mean ± SEM of n = 4 mice; * p<0.05 and ns is not significant.