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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: J Syst Integr Neurosci. 2016 Apr 30;2(2):135–140. doi: 10.15761/JSIN.1000123

Figure 2. Effect of rifampicin treatment on 125I-Aβ40 clearance from the brain of C57BL/6, BALB/c, FVB/N and SJL/J wild-type mice.

Figure 2

Total 125I-Aβ40 brain clearance (BCITotal(%)) (A), BBB 125I-Aβ40 clearance (BCIBBB(%)) (B) and clearance of 125I-Aβ40 by brain degradation (BCIDegradation(%)) (C) from the brain of normal saline and rifampicin treated mice. Significant enhancement in total and BBB clearance of 125I-Aβ40 from the brain was observed in all mouse strains after treatment with rifampicin except in SJL/J mice, where a significant reduction in 125I-Aβ40 clearance was observed after treatment with rifampicin. On the other hand, 125I-Aβ40 degradation was decreased significantly after treatment with rifampicin in all mouse strains except C57BL/6 mice. Data represent mean±SEM for n=4 mice; * p<0.05, ** p<0.01 and ns is not significant.