Skip to main content
. Author manuscript; available in PMC: 2017 Apr 22.
Published in final edited form as: Expert Rev Precis Med Drug Dev. 2016 Apr 22;1(3):235–243. doi: 10.1080/23808993.2016.1175299

Figure 2. Correction and Potentiation of CFTR.

Figure 2

A. Correctors promote transfer of mutant CFTR from the ER to the apical membrane, whereas potentiators enhance activity of apical CFTR. B. Trafficking defect of F508del-CFTR. Confocal immunofluorescence images show apical WT and intracellular-retained F508del-CFTR (green) expressed as Extope-variant in primary HBE cells. Cilia are stained in red and nuclei in blue.