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Drug inhibition of MEK suppresses metabolic activity of MDA-MB-231 cells. The graph shows mean values ± SEM (N = 6 per condition) of extracellular acidification and oxygen consumption rates of MDA-MB-231 cancer cells untreated or pretreated with PD0325901; higher extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) indicate greater metabolic activity. i, baseline; ii, after glucose injection; and iii, after oligomycin injection.
