Figure 2.

Pre-existing immunity at the time of vaccination does not result in markedly increased titers. Samples tested in the ELISAs described in Figure 1 were grouped according to immune status at the time of vaccination. DENV-immune (2) and DENV–naïve individuals (7) are shown as individual symbols for A) UV-DENV ELSIA, B) E protein ELISA, and C) EDIII ELISA. The pre-immune status was unknown (undefined) for 14 samples, represented in gray bar graphs for each ELISA readout. Box and whisker plots indicate the min to max values.