Table 3.
Rotavirus vaccination compliance and completion per PI guidelines.11
| Total (n = 658,219) | All RV vaccinated (n = 392,957) | RV1 cohort (n = 47,766) | RV5 cohort (n = 345,191) | p-value RV1 vs. RV5 | |
|---|---|---|---|---|---|
| Compliance | |||||
| Infants fully compliant, n (%)2 | 113,619 (17.3) | 113,619 (28.9) | 26,013 (54.5) | 87,606 (25.4) | <0.0001 |
| 2008 | 13,522 (15.3) | 13,522 (26.0) | 594 (45.3) | 12,928 (25.5) | <0.0001 |
| 2009 | 28,050 (16.9) | 28,050 (28.3) | 5,930 (50.4) | 22,120 (25.3) | <0.0001 |
| 2010 | 30,622 (16.6) | 30,622 (29.1) | 6,414 (54.9) | 24,208 (25.9) | <0.0001 |
| 2011 | 28,915 (17.6) | 28,915 (29.7) | 8,321 (53.4) | 20,594 (25.2) | <0.0001 |
| 2012 | 10,852 (23.0) | 10,852 (31.9) | 4,089 (64.8) | 6,763 (24.4) | <0.0001 |
| 2013 | 1,658 (19.6) | 1,658 (31.9) | 665 (59.5) | 993 (24.4) | <0.0001 |
| Infants who were non-compliant, n (%) | 279,338 (42.4) | 279,338 (71.1) | 21,753 (45.5) | 257,585 (74.6) | <0.0001 |
| Non-compliant with the first dose, n (%) | 66,636 (10.1) | 66,636 (17.0) | 1,329 (2.8) | 65,307 (18.9) | <0.0001 |
| Non-compliant with the second dose, n (%) | 158,994 (24.2) | 158,994 (40.5) | 20,424 (42.8) | 138,570 (40.1) | <0.0001 |
| Non-compliant with the third dose, n (%) | 53,708 (8.2) | 53,708 (13.7) | N/A | 53,708 (15.6) | N/A |
| Completion | |||||
| Infants who completed all doses, n (%)2 | 178,204 (27.1) | 178,204 (45.3) | 26,038 (54.5) | 152,166 (44.1) | <0.0001 |
| 2008 | 23,113 (26.1) | 23,113 (44.5) | 597 (45.5) | 22,516 (44.5) | 0.4530 |
| 2009 | 44,360 (26.8) | 44,360 (44.7) | 5,937 (50.5) | 38,423 (43.9) | <0.0001 |
| 2010 | 47,843 (26.0) | 47,843 (45.4) | 6,416 (54.9) | 41,427 (44.2) | <0.0001 |
| 2011 | 43,877 (26.7) | 43,877 (45.1) | 8,332 (53.5) | 35,545 (43.5) | <0.0001 |
| 2012 | 16,609 (35.2) | 16,609 (48.8) | 4,091 (64.9) | 12,518 (45.2) | <0.0001 |
| 2013 | 2,402 (28.4) | 2,402 (46.3) | 665 (59.5) | 1,737 (42.6) | <0.0001 |
| Infants who did not complete all doses, n (%) | 214,753 (32.6) | 214,753 (54.7) | 21,728 (45.5) | 193,025 (55.9) | <0.0001 |
| Received only the first dose, n (%) | 122,561 (18.6) | 122,561 (31.2) | 21,728 (45.5) | 100,833 (29.2) | <0.0001 |
| Received the first and the second doses only, n (%) | 92,192 (14.0) | 92,192 (23.5) | N/A | 92,192 (26.7) | N/A |
| Received DTaP vaccination, n (%)2 | 446,243 (67.8) | 390,200 (99.3) | 47,402 (99.2) | 342,798 (99.3) | 0.0913 |
| 2008 | 62,471 (70.5) | 51,361 (98.9) | 1,300 (99.1) | 50,061 (98.9) | 0.4301 |
| 2009 | 113,916 (68.7) | 98,520 (99.3) | 11,686 (99.4) | 86,834 (99.3) | 0.1855 |
| 2010 | 119,205 (64.8) | 104,676 (99.4) | 11,589 (99.1) | 93,087 (99.4) | 0.0007 |
| 2011 | 107,687 (65.6) | 96,663 (99.4) | 15,471 (99.3) | 81,192 (99.4) | 0.0305 |
| 2012 | 37,389 (79.3) | 33,843 (99.5) | 6,258 (99.2) | 27,585 (99.6) | 0.0005 |
| 2013 | 5,575 (66.0) | 5,137 (99.0) | 1,098 (98.3) | 4,039 (99.2) | 0.0107 |
| Completed DTaP vaccination, n (%)2 | 218,472 (33.2) | 203,149 (51.7) | 22,863 (47.9) | 180,286 (52.2) | <0.0001 |
| 2008 | 30,593 (34.5) | 27,273 (52.5) | 601 (45.8) | 26,672 (52.7) | <0.0001 |
| 2009 | 56,399 (34.0) | 51,843 (52.2) | 5,475 (46.6) | 46,368 (53.0) | <0.0001 |
| 2010 | 58,256 (31.7) | 54,353 (51.6) | 5,797 (49.6) | 48,556 (51.9) | <0.0001 |
| 2011 | 52,498 (32.0) | 49,855 (51.3) | 7,340 (47.1) | 42,515 (52.1) | <0.0001 |
| 2012 | 18,229 (38.7) | 17,394 (51.1) | 3,077 (48.8) | 14,317 (51.7) | <0.0001 |
| 2013 | 2,497 (29.6) | 2,431 (46.8) | 573 (51.3) | 1,858 (45.6) | 0.0008 |
PI, package insert; RV, rotavirus; RV1, Rotarix™, GSK Vaccines; RV5, RotaTeq, Merck & Co, Inc.; DTaP, diphtheria-tetanus-pertussis vaccination; N/A, not applicable.
1
Compliance was based on PI dosing schedules described in Table 1. Completion was defined as receipt of two doses of RV1 by 24 weeks of age (RV1 cohort) or three doses of RV5 by 32 weeks of age (RV5 cohort).
2
Percentages shown were calculated using the number of infants born in the relevant year