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. 2016 Jul 27;11(7):e0159709. doi: 10.1371/journal.pone.0159709

Fig 5. Boost by head-only RSV F immunogen can focus the RSV-neutralizing response to antigenic sites Ø and II.

Fig 5

(A) Recognition of DS-Cav1, DS-Cav1 site Ø knockout (KO) and DS-Cav1 site II KO probes by sera from 2×DS-Cav1 immunized mice boosted with DS-Cav1, i-447 or i-693, respectively or unimmunized mice. (B) Neutralization competition of sera from 2×DS-Cav1 immunized mice boosted with DS-Cav1, i-447 or i-693, respectively. P values for differences between DS-Cav1 and DS-Cav1 site Ø or site II KO probes were all <0.0001. P values were determined by two-tailed Mann-Whitney test.