Table 3. Genes (24) upregulated by both Pthrp ablation and microgravity and downregulated by PTHrP1-36 treatment.
| Target ID | Definition (all probes: Mus musculus) | RefSeqID | Fold change PTHrP 1–36 treatment | C |
|---|---|---|---|---|
| AQP5 | aquaporin 5 (Aqp5), mRNA.PREDICTED: similar to aquaporin 5 (LOC100046616), mRNA. | NM_009701.4XM_001476512.1 | 0.37050890.4987479 | A |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (Tnfrsf11b), mRNA. | NM_008764.3 | 0.4687011 | B |
| HSPB1 | heat shock protein 1 (Hspb1), mRNA. | NM_013560.1 | 0.4871401 | HS |
| MRPPLF3 | prolactin family 2, subfamily c, member 4 (Prl2c4), mRNA. | NM_011954.2 | 0.5052176 | P |
| NKD2 | naked cuticle 2 homolog (Drosophila) (Nkd2), mRNA. | NM_028186.3 | 0.5150308 | W |
| PLF2 | prolactin family 2, subfamily c, member 3 (Prl2c3), mRNA. | NM_011118.1 | 0.5191368 | P |
| BDNF | brain derived neurotrophic factor (Bdnf), transcript variant 3, mRNA. | NM_001048141.1 | 0.5334656 | B |
| TIMP3 | tissue inhibitor of metalloproteinase 3 (Timp3), mRNA. | NM_011595.2NM_011595.2 | 0.53376130.6267908 | E |
| CRYAB | crystallin, alpha B (Cryab), mRNA. | NM_009964.1 | 0.5387105 | B |
| ASS1 | argininosuccinate synthetase 1 (Ass1), mRNA. | NM_007494.3 | 0.5595178 | |
| ESD | esterase D/formylglutathione hydrolase (Esd), mRNA. | NM_016903.2 | 0.5693265 | |
| INHBA | inhibin beta-A (Inhba), mRNA. | NM_008380.1 | 0.5792015 | B |
| CD44 | CD44 antigen (Cd44), transcript variant 2, mRNA | NM_001039150.1 | 0.5834 | B |
| GREM1 | gremlin1 (Grem1) mRNA. | NM_011824.1 | 0.5978743 | B |
| GDF15 | growth differentiation factor 15 (Gdf15), mRNA. | NM_011819.1 | 0.5985932 | T |
| MUSTN1 | musculoskeletal, embryonic nuclear protein 1 (Mustn1), mRNA. | NM_181390.1 | 0.6015734 | B |
| MDM2 | transformed mouse 3T3 cell double minute 2 (Mdm2), mRNA. | NM_010786.2 | 0.6034403 | |
| KCTD10 | potassium channel tetramerisation domain containing 10 (Kctd10), mRNA. | NM_026145.3 | 0.61132 | IC |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 (Eef1a2), mRNA. | NM_007906.2 | 0.6231256 | A |
| WHRN | whirlin (Whrn), transcript variant 3, mRNA | NM_001008792.1 | 0.6237 | |
| EPHX1 | epoxide hydrolase 1, microsomal (Ephx1), mRNA | NM_010145.2 | 0.6255 | |
| HIST1H4H | histone cluster 1, H4h (Hist1h4h), mRNA | NM_153173.2 | 0.635 | H |
| STMN2 | stathmin-like 2 (Stmn2), mRNA | NM_025285.2 | 0.645 | B |
| SCX | scleraxis (Scx), mRNA. | NM_198885.2 | 0.6553575 | B |
All -fold changes < 0.66, all p values < 0.05. Multiple entries for a gene indicate multiple probes. C: Clustering: A: apoptosis/survival, B: bone metabolism and bone morphogenic proteins, E: extracellular matrix, H: histone, HS: heat shock, IC: ion channel, P: prolactin, T: tumor growth factor, W: Wnt.