Table 3. Effect of analgesic agents on non-pain specific behaviours.
Data are expressed as median (interquartile range) of behavioural frequency over 10 minute observation period unless duration indicated.
| saline alone | saline + carprofen | saline + buprenorphine | saline + tramadol | 5-FU alone | 5-FU + carprofen | 5-FU + buprenorphine | 5-FU +tramadol | |
|---|---|---|---|---|---|---|---|---|
| Baseline | ||||||||
| High rear | 0 (2) | 0 (0) | 1 (3.5) | 0 (0) | 0 (0)§ (base, 50) | 0 (0)* | 0 (2) | 1(0.75) |
| Abdominal groom | 2.5 (4) | 1 (0.5) | 1 (1) | 0 (0) | 0.5 (2.5) | 0 (0) | 2.5 (2.5) | 1 (0.75) |
| Stop | 2 (3.5) | 1 (1.5) | 2 (3.5) | 0 (3) | 3.5 (2.25) | 0 (0.5)† | 3 (3.75) | 6 (1.5)* |
| Sleep Duration (s) | 364 (563) | 516 (237) | 149 (295) | 600 (185) | 377 (230) | 490 (179) | 79 (247) | 290 (219) |
| 48 Hours | ||||||||
| High rear | 0 (0) | 0 (0)§ (48,50) | 0 (1) | 0 (2.5) | 0 (0.5) | 0 (0) | 0 (0) | 0 (0) |
| Abdominal groom | 1 (2) | 1 (1) | 0 (2) | 1 (1.5) | 0.1 (2) | 1.5 (3) | 0 (0.5) | 1 (1) |
| Stop | 0.5 (4.5) | 0 (1.5) | 1 (3.5) | 5 (5.5)*§ (base, 48) | 4 (2) | 4.5 (3.25)§(base, 48) | 1 (0.75)† | 4.5 (5.25) |
| Sleep Duration | 402 (333) | 478 (129) | 582 (597) | 0 (194)* | 402 (143) | 177 (440) | 543 (185)§ (base, 48) | 0 (0)†§(base, 48) |
| 50 Hours | ||||||||
| High rear | 1 (2) | 1 (2.5) | 0 (0) | 0 (0) | 1.5 (5.5) | 0 (0.5) | 0 (0.5) | 0.5 (2.5) |
| Abdominal groom | 2 (0.75) | 2 (4) | 0 (0) | 1 (2) | 1 (1.75) | 1 (1.5) | 0 (0)*† | 0.5 (1.5) |
| Stop | 3 (2.25) | 2 (2.5) | 1 (2.5) | 4 (5) | 5.5 (3.75) | 1.5 (2.5) | 3 (3) | 2.5 (5.25) |
| Sleep Duration | 46 (292) | 157 (302) | 534 (109) | 415 (433) | 98 (94) | 366 (183) | 337 (252) | 63.5 (177) |
* indicates statistical significance at p < 0.05 compared to saline alone.
† indicates statistical significance at p < 0.05 compared to 5-FU alone.
§ represents significant difference between time points within the same group, superscript value shows the time points that are statistically different.