Table 4. Effects of analgesic agents on visceral organ weights of female Dark Agouti rats 72 hr after 5-FU or saline injection.

Organ weights were calculated as % (wtg/g/bwt) and are expressed as mean % ± SEM. All values are x 10⁻².

	saline alone	saline + carprofen	saline + buprenorphine	saline + tramadol	5-FU alone	5-FU + carprofen	5-FU + buprenorphine	5-FU +tramadol
Thymus	20 ± 1	20 ± 2	17± 1	20 ± 1	8 ± 1*	8 ± 1*	5 ± 1*†	6 ± 1*†
Liver	393 ± 12	440 ± 9*	357 ± 6*	389 ± 22	388 ± 1	429 ± 9*†	381 ± 9	347 ± 9*†
Spleen	21 ± 1	23 ± 1*	23 ± 1	21 ± 1	17 ± 1*	18 ± 1*	15 ± 1*	16 ± 1*
Left Kidney	41 ± 1	47 ± 1*	42 ± 1	41 ± 2	44 ± 1	50 ± 1*†	47 ± 2*	39 ± 2†
Right Kidney	43 ± 1	48 ± 1*	43 ± 1	42 ± 2	45 ± 1	50 ± 1*†	49 ± 1*	40 ± 1†
Adrenal Glands	2 ± 0.1	2 ± 0.3	2 ± 0.1	2 ± 0.1	2 ± 0.1	3 ± 0.1	3 ± 0.1	3 ± 0.1

* indicates statistical significance at p < 0.05 compared to saline alone.

† indicates statistical significance at p < 0.05 compared to 5-FU alone.