. 2016 Jul 27;11(7):e0158851. doi: 10.1371/journal.pone.0158851

Table 6. Effects of analgesic agents on blood biochemistry values of female Dark Agouti rats 72 hr after 5-FU or saline injection.

Data are expressed as median values with experimental group range in brackets. Shaded results are outside references range values given by Giknis and Clifford, 2008 (Charles River labs for inbred Wistars).

	saline alone	saline + carprofen	saline + buprenorphine	saline + tramadol	5-FU alone	5-FU + carprofen	5-FU + buprenorphine	5-FU + tramadol	Ref Interval
Alkaline phosphatase (U/L)	77.0 (32–135)	114.0 (99–135) ^†	99.5 (85–115)	-	60.5 (42–139)	63.0(60–85)	64.5 (57–71)	-	26–147
Alanine Transaminase(U/L)	42.0 (24–46)	51.0 (38–61) ^†	46.0 (31–69) ^†	-	30.0 (18–42)	29.0 (21–40)	40.5 (33–56)	-	16–48
Amylase (U/L)	399.0 (380–546)	380.0 (316–1040)	385.0 (295–399) ^†	-	553.0 (371–645)	509.0 (446–776)	451.0 (389–550)	-	NA
Ca:P ratio	0.8 (0.6–1.1)	0.8 (0.7–0.8)	0.7 (0.5–0.9)	-	0.9 (0.5–1.2)	0.8 (0.7–0.8)	0.7 (0.4–0.8)	-	NA
Creatinine Kinase (U/L)	631 (255–1776)	304 (188–599)	428 (120–700)	-	300 (98–1182)^*	444 (230–2019)	346 (165–1222)	-	163–1085
Creatinine (μmol/L)	21.9 (18–27)	21.5 (19–24)	27.5 (22–39)	26.0 (21–31)	28.0 (20.6–33)^*	26.0 (23–31)^*	34.5 (28–45) ^*^†	32.2 (28–41) ^*^†	11–33
Glucose (mmol/L)	7.0 (5–10)	10 (7–13)	12.0 (7–13)^*^†	-	7.3 (3–10)	9.5(7–12)	9.5 (6–16) ^†	-	4.2–9.7
Na:K ratio	22.4 (18–26)	20.8 (20–29)	20.4 (18–23) ^†	-	24.6 (20–30)	25.9 (20–29)	24.3 (20–25)	-	NA
Total Protein (g/L)	58.0 (55–64)	51.5 (50–56) ^*^†	59.0 (55–62)	-	59.0 (52–63)	48.5 (43–57) ^*^†	56.5 (42–66)	-	55–77
Urea (mmol/L)	5.0 (4–6)	5.0 (4–5)	5.5 (5–9)	6.0 (5–7)	4.3 (3–7)	5.0 (4–6)	4.1 (4–6) ^*	7.3 (5–8) ^*^†	13.2–27.1

* indicates statistical significance at p < 0.05 compared to saline alone.

† indicates statistical significance at p < 0.05 compared to 5-FU alone.