Table 3. All-cause mortality and breast-cancer-specific mortality.
A: Mortality rate ratios (MRRs) for the all-cause mortality ten years after a breast cancer diagnosis for women with SMI and breast cancer compared to women with breast cancer only (N = 42,419), 1980–2012 | ||||||
Total deaths | MRR (95% CI) | |||||
Without SMI | With SMI | Model 1a | Model 2 b | Model 3 c | Model 4d | |
With SMI vs. without SMI | 41,771 | 648 | 1.60 (1.48–1.73) | 1.59 (1.47–1.72) | 1.57 (1.45–1.70) | 1.46 (1.36–1.58) |
With schizo vs. without schizo† | 41,998 | 421 | 1.73 (1.57–1.90) | 1.70 (1.54–1.87) | 1.71 (1.56–1.89) | 1.60 (1.45–1.76) |
With bipol vs. without bipol†† | 42,192 | 227 | 1.39 (1.22–1.59) | 1.41 (1.24–1.61) | 1.35 (1.18–1.54) | 1.26 (1.10–1.43) |
B: MRRs for breast-cancer-specific cause of death ten years after a breast cancer diagnosis for women with SMI and breast cancer compared to women with breast cancer only (N = 26,078), 1980–2010 | ||||||
Total deaths | MRR (95% CI) | |||||
Without SMI | With SMI | Model 1a | Model 2 b | Model 3 c | Model 4d | |
With SMI vs. without SMI | 25,731 | 347 | 1.38 (1.24–1.54) | 1.35 (1.21–1.50) | 1.34 (1.21–1.49) | 1.29 (1.16–1.44) |
With schizo vs. without schizo† | 25,840 | 238 | 1.55 (1.36–1.76) | 1.49 (1.31–1.70) | 1.49 (1.31–1.70) | 1.44 (1.27–1.64) |
With bipol vs. without bipol†† | 25,969 | 109 | 1.12 (0.93–1.35) | 1.11 (0.92–1.34) | 1.09 (0.90–1.32) | 1.05 (0.87–1.27) |
Abbreviations: MRR: mortality rate ratio; SMI: severe mental illness; CI: confidence interval; schizo: schizophrenia; bipol: bipolar affective disorder.
aAdjusted for age and calendar period.
bAlso adjusted for tumor stage of breast cancer.
cAlso adjusted for medical comorbidity (i.e., diabetes and the CCI -score, excluding diabetes-related diseases and cancers).
dAlso adjusted for substance abuse.
†The ‘No schizophrenia’ -group comprised persons in the general population, including persons with bipolar affective disorder.
††The ‘No bipolar affective disorder’ -group comprised persons in the general population, including persons with schizophrenia.