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. 2016 Jul 27;11(7):e0158013. doi: 10.1371/journal.pone.0158013

Table 3. All-cause mortality and breast-cancer-specific mortality.

A: Mortality rate ratios (MRRs) for the all-cause mortality ten years after a breast cancer diagnosis for women with SMI and breast cancer compared to women with breast cancer only (N = 42,419), 1980–2012
Total deaths MRR (95% CI)
Without SMI With SMI Model 1a Model 2 b Model 3 c Model 4d
With SMI vs. without SMI 41,771 648 1.60 (1.48–1.73) 1.59 (1.47–1.72) 1.57 (1.45–1.70) 1.46 (1.36–1.58)
With schizo vs. without schizo 41,998 421 1.73 (1.57–1.90) 1.70 (1.54–1.87) 1.71 (1.56–1.89) 1.60 (1.45–1.76)
With bipol vs. without bipol†† 42,192 227 1.39 (1.22–1.59) 1.41 (1.24–1.61) 1.35 (1.18–1.54) 1.26 (1.10–1.43)
B: MRRs for breast-cancer-specific cause of death ten years after a breast cancer diagnosis for women with SMI and breast cancer compared to women with breast cancer only (N = 26,078), 1980–2010
Total deaths MRR (95% CI)
Without SMI With SMI Model 1a Model 2 b Model 3 c Model 4d
With SMI vs. without SMI 25,731 347 1.38 (1.24–1.54) 1.35 (1.21–1.50) 1.34 (1.21–1.49) 1.29 (1.16–1.44)
With schizo vs. without schizo 25,840 238 1.55 (1.36–1.76) 1.49 (1.31–1.70) 1.49 (1.31–1.70) 1.44 (1.27–1.64)
With bipol vs. without bipol†† 25,969 109 1.12 (0.93–1.35) 1.11 (0.92–1.34) 1.09 (0.90–1.32) 1.05 (0.87–1.27)

Abbreviations: MRR: mortality rate ratio; SMI: severe mental illness; CI: confidence interval; schizo: schizophrenia; bipol: bipolar affective disorder.

aAdjusted for age and calendar period.

bAlso adjusted for tumor stage of breast cancer.

cAlso adjusted for medical comorbidity (i.e., diabetes and the CCI -score, excluding diabetes-related diseases and cancers).

dAlso adjusted for substance abuse.

The ‘No schizophrenia’ -group comprised persons in the general population, including persons with bipolar affective disorder.

††The ‘No bipolar affective disorder’ -group comprised persons in the general population, including persons with schizophrenia.