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The first search was performed on 4 July 2013, using the terms relating to (breast tumor OR breast cancer) AND (trastuzumab OR Herceptin) (See S1 Table). On 18 September 2014, we added three further terms to expand the search with previous names of trastuzumab: (breast tumor OR breast cancer) AND ("rhuMAb HER2" OR "Anti-p185HER2 Monoclonal Antibody" OR "muMAb 4D5”).
