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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Clin Exp Ophthalmol. 2015 Feb 12;43(4):358–366. doi: 10.1111/ceo.12299

Figure 3.

Figure 3

Quantifying gold nanorod (GNR) detection limit in the anterior chamber (AC) in vivo. (a) Mice ACs were injected with 3–5 μL of GNR-850 nanoparticles at decreasing concentrations from 30 nM to 0 nM (N = 12 total mice). Control mice ACs were injected with Matrigel. Although mice injected with 29 pM of GNR-850 solution displayed contrast similar to control mice, concentrations of 120 pM and above produced a distinct detectable OCT signal. (b) Quantification of the OCT contrast (measured as signal from area of injection divided by signal from an area distant from the injection) was observed to increase with the GNR concentration, with the lowest detectable concentration being 120 pM. Below this concentration, the OCT contrast was about equal to the OCT contrast recorded from the control mice (denoted as Background in black dashed line). The error bars represent standard deviation of the OCT signal.