Table 1.
Statistical analysis of biomarkers (21 OH-AA, PRA, ACTH, baseline Cortisol and peak Cortisol following cortrosyn stimulation). Time in progressors is divided into >2 years and 2 months–2 years prior to the onset of AD. These progressor means are compared to each other and to nonprogressor values
| n (samples) | Minimum | 25% | Median | 75% | Maximum | Mean | SEM | CI 95% | |
|---|---|---|---|---|---|---|---|---|---|
| (A) | |||||||||
| 21OH-AA | |||||||||
| NP | 236 | 0·16 | 0·7 | 0·9 | 1·1 | 3·0 | 0·9 | 0·027 | 0·86–0·97 |
| Progressor > 2 years | 23 | 0·76 | 1·0 | 1·3 | 1·7 | 2·1 | 1·3 | 0·077 | 1·16–1·50 |
| Progressor 2 months–2 years | 18 | 0·82 | 1·1 | 1·3 | 1·8 | 2·1 | 1·4 | 0·090 | 1·20–1·58 |
| Renin | |||||||||
| NP | 99 | 0 | 0·8 | 1·6 | 3·3 | 19·7 | 3·1 | 0·408 | 2·3–4·0 |
| Progressor >2 years | 9 | 0·8 | 1·6 | 3·2 | 5·2 | 6·9 | 3·3 | 0·694 | 1·7–5·0 |
| Progressor 2 months–2 years | 8 | 0·5 | 1·9 | 3·0 | 6·9 | 10·3 | 4·3 | 1·200 | 1·4–7·1 |
| ACTH | |||||||||
| NP | 135 | 0 | 2·7 | 4·0 | 5·7 | 21·6 | 4·8 | 0·288 | 4·2–5·3 |
| Progressor >2 years | 14 | 1·5 | 2·4 | 3·9 | 10·2 | 17·2 | 6·3 | 1·412 | 3·2–9·3 |
| Progressor 2 months–2 years | 10 | 5·9 | 9·9 | 13·0 | 18·8 | 31·7 | 15·1 | 2·301 | 9·9–20·3 |
| Baseline cortisol | |||||||||
| NP | 125 | 80 | 193·2 | 276 | 386·4 | 993·6 | 298·7 | 13·1 | 272·8–324·7 |
| Progressor > 2 years | 14 | 166 | 248·4 | 409·9 | 560·3 | 1380 | 474·7 | 83·6 | 294·1–655·3 |
| Progressor 2 months–2 years | 10 | 237 | 266·3 | 309·1 | 510·6 | 679 | 372·3 | 47·3 | 265·4–479·3 |
| Peak cortisol | |||||||||
| NP | 107 | 442 | 690·0 | 800·4 | 910·8 | 1297 | 808·2 | 18·3 | 771·9–844·4 |
| Progressor > 2 years | 12 | 469 | 666·5 | 772·8 | 869·4 | 2180 | 887·3 | 131·5 | 598–1177 |
| Progressor 2 months–2 years | 7 | 466 | 469·2 | 552 | 706·6 | 855·6 | 597·3 | 54·7 | 463·5–731·2 |
| (B) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 21 OH-AA |
Renin |
ACTH |
Baseline cortisol |
Peak cortisol |
||||||
| 21 OH-AA+ group | Mean difference | P | Mean difference | P | Mean difference | P | Mean difference | P | Mean difference | P |
| NP vs progressor 2 months–2 years | –0·48 | <lE-4 | –1·15 | 0·1 | –10·29 | <1E-4 | –73·60 | 0·12 | 210·90 | 5·E-03 |
| NP vs progressor > 2 years | 0·41 | <lE-4 | 0·19 | 0·13 | 1·54 | 0·7 | 176·00 | 0·01 | 79·10 | 0·83 |
| Progressor 2 months–2 years vs progressor > 2 years | 0·07 | 0·49 | 0·95 | 0·74 | 8·75 | 3·E-03 | –102·40 | 0·52 | –290·00 | 0·05 |
P-values derived from Mann-Whitney U-Test. 21 OH-AA, 21-hydroxylase autoantibodies; AD, Addison's disease; PRA, plasma renin activity; NP, nonprogressor values.