Figure 6. A model depicting transcriptional changes of metabolic genes underlying the switch from aerobic glycolysis in NPCs to oxidative phosphorylation in neurons.
The genes with decreased expression are dimmed. The width of the arrows indicates increased and decreased pyruvate and lactate utilization at different steps in NPCs and neurons. Abbreviations: glucose 6-phosphate (G6P); fructose 1,6-bisphosphate (FBP); glycerol 3-phosphate (G3P); dihydroxyacetone phosphate (DHAP); 1,3-bisphosphoglyceric acid (BPG); 3-phosphoglyceric acid (3PG); phosphoenolpyruvic acid (PEP).