Appendix 2–figure 4. Impact of number of E-boxes and NNNNNN sequences.

Different combinations of number of E-boxes and NNNNNN sequences are assumed in the simulations: $[Ebo{x}_{total}]=9.3\cdot {\text{10}}^{\text{5}}$ and $[NNNNN{N}_{total}]=9.\text{5}\cdot {\text{10}}^{\text{9}}$ represent the reference values and the range of 50% to 200% of these reference values is taken into account. Surfaces of equal occupancy of E-boxes are shown as function of dissociation constants $K_{NNNNNN}$ and $K_{Ebox}$ as well as total amount of MYC.

DOI: http://dx.doi.org/10.7554/eLife.15161.026