Skip to main content
. Author manuscript; available in PMC: 2017 Apr 19.
Published in final edited form as: ChemMedChem. 2016 Mar 30;11(8):850–861. doi: 10.1002/cmdc.201600021

Table 3.

Phenotypic screening of R1 analogs in CML cell lines.

graphic file with name nihms800395u4.jpg
Compound ID R1 IC50 AR230 (μm) IC50 AR230R (μm) Fold Difference LogP[a]
PSL-3-115 H 5.2 2.3 2.26 3.39
PSL-3-122 F 6.1 3 2.03 3.36
DR-4-003 Cl 4.1 1.7 2.41 3.68
DR-3-186 CF3 1.4 0.72 1.94 3.95
PSL-3-132 c-Pr 4.2 2.4 1.75 3.86
DR-4-020 c-Bu 8.6 4.2 2.05 4.05
DR-3-162 t-Bu 3.2 0.8 4 4.24
DR-3-093 c-Pent 3.3 1.2 2.75 4.23
DR-3-165 c-Hept 2.7 1.1 2.45 4.8
DR-3-119 graphic file with name nihms800395t1.jpg 5.8 3.2 1.81 4.84
PSL-3-089 graphic file with name nihms800395t2.jpg 7.4 5.2 1.42 3.29
DR-4-042 graphic file with name nihms800395t3.jpg 4.7 4.2 1.12 3.29
[a]

Values calculated by StarDrop.