Table 3. p53 Regulated lncRNA in GI Cancer.
| lncRNA | Transcriptional Target |
Tumor Suppressor/ Oncogene |
Function | Ref. |
|---|---|---|---|---|
| lincRNA-p21 | Yes | * | ↑Apoptosis, ↑Cell Cycle Arrest, ↑Radiation Sensitivity, ↑Hypoxia Resistance |
77, 79, 81– 83 |
| Pint | Yes | Tumor Suppressor | ↑Apoptosis, ↓Proliferation |
84 |
| Tusc7 | Yes | Tumor Suppressor | ↓Proliferation, | 85– 89 |
| Tug1 | Yes | * | ↑Proliferation,
↑Migration/Invasion, ↑EMT, ↑Radiation Resistance |
91– 93 |
| LED | Yes | * | ↑Cell Cycle Arrest | 94, 95 |
| PR-lncRNA-1 | Yes | Tumor Suppressor | ↑Apoptosis, ↓Proliferation |
96 |
| PR-lncRNA-10 | Yes | Tumor Suppressor | ↑Apoptosis, ↓Proliferation |
96 |
| PVT1 | Yes | * | ↑Proliferation ↓Apoptosis |
50, 97 |
| LincRNA-ROR | Yes | * | ↓Apoptosis, ↓Cell Cycle Arrest |
98, 105, 106 |
*--Role not clear, or conflicting reports in different cancer types