Table 4. lncRNA that regulate p53 in GI Cancer.
| lncRNA | Regulation +/- | Tumor Suppressor/ Oncogene |
Function | Ref. |
|---|---|---|---|---|
| MEG3 | + | Tumor Suppressor | ↓Proliferation | 100 |
| H19 | - | Oncogene | ↑Proliferation, ↓Apoptosis |
101 |
| MALAT-1 | - | Oncogene | ↑Cell Cycle Progression, ↑Migration/Invasion |
102– 104 |
| LincRNA-ROR | - | * | ↓Apoptosis, ↓Cell Cycle Arrest |
98, 105, 106 |
*--Role not clear, or conflicting reports in different cancer types