Skip to main content
. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Nat Rev Mol Cell Biol. 2015 Feb 18;16(3):155–166. doi: 10.1038/nrm3951

Figure 3. Mediator regulates chromatin architecture.

Figure 3

The cooperative interactions between Mediator and transcription factors (TF), cohesin and non-coding RNAs (ncRNA) appear to stabilize enhancer-promoter loops102,134,139,140. An expanding set of factors influence the formation and stability of enhancer-promoter loops1 and the formation of such structures correlates with high levels of transcription125-127. Because the CDK8 module must dissociate from Mediator to allow pol II–Mediator binding18,19, a potential ncRNA–CDK8 module interaction, perhaps via the CDK8 module subunit MED12134, may tether the CDK8 module near the PIC. This could facilitate re-formation of CDK8-Mediator complexes following pol II promoter escape.