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Active Cdc42 for cells of different shapes: an ellipsoid cell (top row, (a)-(c)), and a cell composed of two thinly connected ellipsoids (bottom row, (d)-(f)) at times of 5, 10, and 100s. A stimulus gradient is applied to the initially homogeneous cells. Both cells initially polarize at t = 5s, but the cell with the shape of a single ellipsoid loses its polarization at t = 100s, whereas the cell composed of two ellipsoids is able to maintain its polarization.
