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Genome-wide methylation analysis of human normal and OA knee articular cartilage. a) Unsupervised hierarchical clustering of DNA methylation values in 11 normal samples and 12 OA samples. b) Principal component analysis (PCA) of DNA methylation in the 929 differentially methylated CpG sites (DMS) between normal (black) and OA (red) samples. c) Gene ontology (GO) and d) Pathway analysis of the 929 DMS between normal and OA samples.
